In order to implement the decision-making and deployment of the provincial Party committee, the provincial government and the Provincial Department of science and technology, support the cultivation of "one area, one strategic industry" and the high-quality development of the self created area in southern Jiangsu, and make full use of the advantages of the intelligent service platform of the provincial industry university research cooperation to provide the "invisible" industry university research docking service for the scientific and technological enterprises during the epidemic prevention and control period, the Provincial Productivity Promotion Center released the fifth online technology road on April 2 With the theme of biomedicine and general health, 12 projects from famous universities and institutes such as Peking University, Shanghai Jiaotong University, Sun Yat sen University, Nankai University, Shanghai Pharmaceutical Research Institute, Institute of science and technology of Chinese Academy of Sciences, Nanjing University, Southeast University, and China Pharmaceutical University were selected to release roadshows online and serve technology enterprises in the form of "no meeting" In addition, we will provide supporting integrated services in technology transfer, talent introduction, science and technology finance, inspection and testing, patent services, policy consultation, etc., and accelerate cooperation in projects.
This online technology roadshow (bio medicine and big health topic) was strongly supported by Suzhou Industrial Park, focusing on the in-depth promotion and docking of science and technology enterprises in the park, and fully releasing the innovation vitality of these new technologies, so as to help the development of Suzhou bio medicine industry.
It is reported that as one of the three emerging industries in Suzhou Industrial Park, the biomedical industry has maintained a growth rate of more than 20% for many consecutive years, with an output value of 90 billion yuan in 2019, gathering more than 1400 high-quality enterprises represented by Cinda bio. The park has issued the implementation measures of Suzhou Industrial Park on further promoting the development of biomedical industry, which provides up to 10 million yuan of support funds to eligible enterprises. According to the evaluation and analysis report on the competitiveness of China's biomedical industrial park in 2019 issued by the biotechnology development center of the Ministry of science and technology of the people's Republic of China, the main indicators of Suzhou Industrial Park are among the top, ranking the first in the national biomedical industrial park.
Brief introduction of this project
1. Project 1: Peking University -- koushanone compound with anti hepatitis B virus and liver protection for hepatitis B treatment
Project Description: this project includes two parts. One is to extract and separate the koushankone compounds as the representative of Swertia mussotii to achieve antiviral and hepatoprotective effects by inhibiting the expression of HBsAg and HBeAg. The other is to extract and separate compound 1,7-dihydroxy-3,4,8-trimethoxykoushan ketone (zyc-6), which has the effect of anti fibrosis and liver protection by reducing the activities of ALT and AST.
2. Project 2: Shanghai Jiaotong University: new drug delivery technology based on biomacromolecule
Project introduction: this project has effectively solved the problem of long-acting slow release by using the unique aqueous phase emulsion technology invented by ourselves. It has achieved satisfactory results in the development of long-acting dosage forms such as erythropoietin, auxin, interferon and other protein drugs, and can be used for almost all protein drugs requiring sustained release.
3. Project 3: Sun Yat sen University: clinical study on the treatment of ankylosing spondylitis by allogeneic normal bone marrow mesenchymal stem cells infusion
Project introduction: through the isolation, culture and expansion of normal volunteers' bone marrow mesenchymal stem cells (MSCs), we found that the normal MSCs can significantly reduce the level of inflammation in patients with ankylosing spondylitis (as), in which 21.1% of patients with inflammatory back pain and other symptoms were completely relieved, 52.6% of patients with clinical symptoms were significantly improved, the project was complete The body effective rate was 73.7%. Except for 6.9% patients with fever, no other obvious adverse events and side effects were found. It is proved that MSCs infusion is safe and effective in the treatment of ankylosing spondylitis.
4. Project 4: Nankai University - doxycycline hydrochloride anti-tumor drug development
Project introduction: in this project, we found that doxycycline hydrochloride can interact with matrix metalloproteinases (MMPs) and focal adhesion kinase (FAK), which are related to cell migration and movement. By inhibiting tumor cell adhesion and inducing tumor cell apoptosis, and then inhibiting tumor cell's supporting growth, invasion and blood metastasis, it can play a comprehensive anti-tumor effect.
5. Project 5: Shanghai Institute of medicine, Chinese Academy of Sciences: a new drug against myocardial ischemia-reperfusion injury
Project Description: the project has two authorized patents. The completed pre clinical research results show that it can significantly reduce the myocardial infarction area, improve the cardiac systolic and diastolic function and the symptoms of myocardial hemorrhage, significantly reduce the number of myocardial cell apoptosis and necrosis, and has excellent curative effect. The drug is used in the rescue treatment of myocardial cells in the acute stage of myocardial infarction, and the manufacturer is invited to cooperate in the development.
6. Item 6: Institute of physical and chemical technology, Chinese Academy of Sciences - minimally invasive tumor whole body hyperthermia equipment
Project Description: the project adopts the concept of green treatment, and innovatively proposes to develop the whole body hyperthermia equipment and system in the way of blood vessel interposition. It has won 7 invention patents. It is the first advanced medical equipment that directly heats the blood in a minimally invasive way.
7. Project 7: Nanjing University: replication oncolytic adenovirus with activation of immune costimulatory signaling pathway and blocking of immune checkpoint and its application
Project introduction: in this project, a new type of recombinant replication oncolytic adenovirus nju-007 was constructed, which expressed secretory recombinant fusion protein spdd137l, specifically combined with PD-L1 at the? End, blocked the checkpoint, and specifically combined with CD137 at the? End to provide co stimulation signal. In a variety of mouse tumor models, it can recruit lymphocytes in the tumor area, activate anti-tumor immunity, effectively inhibit the growth of liver cancer, melanoma and breast cancer, significantly prolong the survival time of tumor bearing mice, and generate long-term specific immunity in the cured individuals.
8. Item 8: Nanjing University - Application of babaodan in preparation of drugs for prevention and treatment of liver cancer
Project introduction: babaodan is a bright lamp of traditional Chinese medicine, which is used to remove yellow and protect liver function. This study found that babaodan can inhibit many tumor promoting inflammatory pathways including STAT3, prevent the occurrence of tumor, inhibit the growth of tumor, and restore the immune monitoring of tumor. Therefore, babaodan, a traditional Chinese medicine, has been developed into a new type of immunotherapy and adjuvant therapy for solid tumors, including liver cancer.
9. Project 9: Southeast University - nano composite adhesive coating products for killing airborne infectious viruses
Project introduction: the nanocomposite adhesive coating can be applied on various chemical fiber fabrics or metal nets to kill infectious viruses in the air, which can effectively prevent the spread and spread of various viruses. The nanocomposite adhesive coating product can be used to prevent the spread and spread of covid-19 virus at present, and also can be applied to other new air borne viruses in the future, playing an emergency role before the development of vaccines and effective drugs.
10. Project 10: China Pharmaceutical University - tumor necrosis targeted Radiopharmaceuticals
Project Description: this project has successfully developed a small molecule necrosis targeting compound, which can be used for the treatment of residual tumor after chemotherapy, and has a broad market application prospect.
11. Project 11: China University of mining and technology - medical water jet generator
Project Description: this project combines jet technology and medical engineering in surgical operation, with obvious advantages such as fine separation, flat incision, clear vision and small amount of bleeding. It is a new type of medical operation separation method after relay knife and ultrasonic knife. The high-speed and extremely fine jet water beam formed by spraying physiological saline impacts biological tissues, It can be used in orthopedics, hepatobiliary surgery, neurosurgery, rectal surgery, otorhinolaryngology, head and neck surgery, urology and other clinical operations.
12. Project 12: Nanjing Institute of Engineering RFID medical intelligent storage
Project Description: Based on RFID technology, this project develops the intelligent storage technology applied to the medical industry. Through the cheap RFID wireless electronic tag, it can automatically identify the warehousing and warehousing of high value consumables, which can be traced and recorded, and can be seamlessly linked with the ERP system of the hospital, and can be applied to the unmanned management of high value consumables and drugs in the hospital. At present, the product has become more and more mature, and has been used in many hospitals in China, with good results.
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