Recently, the research group of Professor Zhao Yuanjin from Gulou Hospital of Nanjing University has made the latest research results in the field of micro needle design and application. Inspired by the sucker structure of octopus in nature, the adhesion principle of mussels and the competitive survival characteristics of polymyxomycetes, the members of the research team prepared an antibacterial micro needle with dry and wet adhesion by template replication, and used it for wearable drug delivery. The research results are published in the well-known journal research with the title of "bioinpired adaptive and antiviral microneeds for versatile transmal drug delivery", and Professor Zhao Yuanjin is the only corresponding author of this paper. Micro needle has the advantages of minimally invasive, painless, non-invasive and enhanced drug penetration, which is very suitable for drug delivery through the skin, and has attracted much attention in many medical fields. However, the low skin adhesion and the lack of antibacterial still limit the practical application of microneedles. Therefore, members of the research group introduced the microstructures of the sucker of the octopus tentacles into the microneedle base. The polydopamine gel was used as the base material and an antibacterial polypeptide, polymyxin, was added to the microneedles. A flexible microneedle with multifunctional adhesion and antibacterial ability was developed. Thanks to the polydopamine gel and the sucker like microstructure that surrounds the needle tip, the microneedle can be well adapted to the skin surface, and can be firmly adhered to the skin in the dry and wet environment, and has self-healing characteristics. In addition, because the polymyxin is loaded in the tip and the base of the microneedle, the microneedle has a spectral antibacterial effect on Gram-negative bacteria, which is conducive to preservation and use. In vitro experiments show that the micro needle can adhere to the flexible knuckle and has a good killing effect on E.coli. In vivo experiments in rats show that the micro needle can be used for the release of arthritis drugs for arthritis treatment. These results indicate that this kind of bionic multifunctional micro needle is expected to break the limitation of traditional micro needle and show a broad application prospect in the field of general and wearable transdermal drug delivery.
Relevant research work has been supported by NSFC, Jiangsu Natural Science Foundation and other projects.
Source: polymer science frontier
Statement: only on behalf of the author's personal point of view, the author's level is limited, if there is any unscientific, please leave a message below for correction!
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